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Image Search Results
Journal: The Prostate
Article Title: The identification of a novel antibody for CD133 using human antibody phage display
doi: 10.1002/pros.23656
Figure Lengend Snippet: Case study of a patient with aggressive prostate cancer. A, CT scan of diffuse liver metastases that appeared in the presence of declining PSA after the patient failed treatment with Zytiga (abiraterone). B, Strong staining for CD133 was detected in the liver metastases using HA10. C, No staining for the AR was observed in the liver metastases using an antibody specific to the N-terminal domain of the AR. This antibody would detect both full-length AR and AR splice variants. D, Staining was observed for the neuroendocrine differentiation marker chromogranin A in the liver metastases. E, An original TURP specimen from the patient depicting poorly differentiated Gleason 4 + 5 cancer stained for CD133. Note the complete absence of CD133. F, Liver biopsy from the patient after failing treatment with carboplatin and taxotere documenting moderate staining for CD133. Scale bars, (B-D) 200 μm and (E-F) 60 μm. [Color figure can be viewed at wileyonlinelibrary.com]
Article Snippet: The following primary antibodies and concentrations used were: CD133 HA10 antibody, rabbit monoclonal (1:100); androgen receptor SP107 (Sigma), rabbit monoclonal (1:200);
Techniques: Computed Tomography, Staining, Marker